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One Smart Supplement: Magnesium-L-Threonate

One Smart Supplement: Magnesium-L-Threonate

Protecting the brain is a top concern as we age. Alzheimer's disease affects more than five million Americans, and it's the sixth leading cause of death in the U.S. -- in fact, it kills more than breast and prostate cancer combined, according to the American Alzheimer's Association.

Nutrition and lifestyle go a long way in helping to prevent Alzheimer's and preserve memory and brain power as we get older. Studies find that one nutrient in particular, magnesium-L-threonate, is a key player in protecting the aging brain's structure and function to help prevent memory decline as well as Alzheimer's and other forms of dementia.

Magnesium and the Brain

The brain stores new information by forming connections between neurons. Scientific evidence shows that when synapses, the connections that allow nerve cells to communicate with each other, are diminished, it results in memory impairment. It's thought that this loss of synapses is responsible for age-dependent memory decline.

Magnesium enhances the activity of more than 300 enzymes and plays a critical role in the activation of nerve channels involved in synaptic plasticity -- which means it's essential to the process of memory and learning. Deficiency of this important mineral causes symptoms ranging from memory impairment to psychosis.


Magnesium-L-threonate is a highly absorbable form of magnesium that has the unique ability to permeate the brain and support the brain's receptors involved in memory. Animal research in the journal Neuron finds that increasing magnesium in the brain with supplemental magnesium-L-threonate leads to enhanced learning abilities, working memory, and short- and long-term memory. Study authors concluded, "Our findings suggest that an increase in brain magnesium enhances both short-term synaptic facilitation and long-term potentiation and improves learning and memory functions."

Studies find that magnesium-L-threonate concentrates more efficiently in the brain and helps rebuild damaged synapses and restore degraded connections between neurons like those observed in patients with Alzheimer's disease and other forms of memory loss.

Why You Need a Supplement

Low magnesium status can accelerate brain cell aging and memory loss, and experts estimate that between 70 and 80 percent of the U.S. population does not meet their recommended intakes of magnesium. Standard magnesium offers limited protection because, generally, this mineral is poorly absorbed. (Since magnesium competes with other minerals, like calcium, for absorption, it may be best to take magnesium separately on an empty stomach.) It's particularly challenging to raise magnesium levels in the brain.

Magnesium-L-threonate is the only form of magnesium that has been shown to readily cross the blood-brain barrier to maximize magnesium concentration in the brain, where it's efficiently transferred to the central nervous system to support and enhance neurological function. Additionally, studies find it to be the only form of magnesium that boosted memory, compared to standard supplements.

Look for a supplement formulated to support brain health containing magnesium-L-threonate at your local natural market.

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